Chapter 04 · Evidence

An evidence-informed formulation, transparently presented.

Juvion-001 is built on robust ingredient-level evidence and clinical reasoning. We are honest about what is established, what is emerging, and what is not.

04Research
Where We Sit

Between preventive nutrition and functional supplementation.

Juvion-001 is classified as a food supplement (nutraceutical) under Swiss law. It is not a medicinal product and does not make therapeutic claims. It is best positioned as adjunctive support — alongside exercise, balanced nutrition and medical care — not as treatment.

For healthcare professionals
Ingredient-Level Evidence

A summary of the published evidence base.

CompoundMechanismEvidenceClinical Note
NADH Mitochondrial ATP support · electron transport chain Studied in fatigue-related conditions Occasional headache in sensitive individuals
Creatine Phosphocreatine system buffering Improved muscle strength & function in elderly cohorts Mild GI discomfort dose-dependent
L-Arginine Nitric oxide pathway · endothelial function Endothelial function & perfusion improvements May potentiate hypotensive effects
Grape Seed Polyphenolic antioxidant · OPC activity Antioxidant & endothelial protection Mild anticoagulant — review with bleeding risk
Vitamin D3 Muscle function & neuromuscular signalling Muscle function & fall-risk reduction in deficient individuals Optimise via blood report
Piperine Bioavailability enhancer · neuroprotective potential Enhanced absorption of co-formulated actives Functional dosing

Ingredient-level evidence is robust. Clinicians should differentiate this from drug-level RCT evidence applied to a finished product.

Onset of Effect

Pharmacodynamic expectations.

8–12 weeks

Cellular energy effects

First measurable shifts in cellular energy and fatigue resilience.

12–24 weeks

Neuromuscular performance

Measurable changes in stamina, coordination and responsiveness.

24–52 weeks

Functional improvements

Strength reliability, mobility quality and movement confidence.

Variability increases with age above 75, multimorbidity and sedentary baseline. Best paired with resistance training, balance work, adequate protein and Vitamin D optimisation.

Safety Profile

Generally well tolerated. Always thoughtful.

Used as directed in healthy adults and elderly populations, Juvion-001 is generally well tolerated. We disclose every known consideration so clinicians and users can make informed choices.

Tolerability

Mild & uncommon.

Possible mild GI discomfort (creatine), occasional headache (NADH, rare), mild hypotensive effect (L-arginine).

Caution

Use under guidance.

Chronic kidney disease · polypharmacy in frail elderly · cardiovascular instability · diabetes monitoring.

Avoid or supervise

Always consult.

Advanced renal impairment · complex anticoagulation regimens · pregnancy and lactation.

Drug–Nutrient Considerations

Transparent interaction guidance.

L-arginine may potentiate hypotensive effects. Patients on blood-pressure medication should monitor levels.
Grape seed extract has mild anticoagulant activity. Patients on blood thinners should consult a physician before use.
Generally compatible. Mitochondrial support pathways may complement statin therapy. No major contraindication; monitor as standard.
L-arginine may influence insulin sensitivity. Patients with diabetes should monitor blood glucose, particularly when initiating use.
Creatine metabolism in chronic kidney disease requires medical supervision. Not recommended in advanced renal impairment without specialist input.
Monitoring & Outcomes

What clinicians can track.

  • Grip strength
  • Gait speed
  • Timed up & go (balance)
  • Patient-reported fatigue & mobility
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